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Ji YBA , Tulin AV
The roles of PARP1 in gene control and cell differentiation
Current Opinion in Genetics & Development. 2010 Oct;20(5) :512-518
PMID: ISI:000282864300008 PMCID: PMC2942995
AbstractCell growth and differentiation during developmental processes require the activation of many inducible genes. However, eukaryotic chromatin, which consists of DNA and histones, becomes a natural barrier impeding access to the functional transcription machinery. To break through the chromatin barrier, eukaryotic organisms have evolved the strategy of using poly(ADP-ribose) polymerase 1 (PARP1) to modulate chromatin structure and initiate the steps leading to gene expression control. As a structural protein in chromatin, enzymatically silent PARP1 inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription. However, once activated by environmental stimuli and developmental signals, PARP1 can modify itself and other chromatin-associated proteins, thereby loosening chromatin to facilitate gene transcription. Here we discuss the roles of PARP1 in transcriptional control during development.
NotesJi, Yingbiao Tulin, Alexei V. National Institutes of Health [R01DK082623] We thank Dr Hua-Ying Fan for her critical reading of the manuscript and valuable comments. The expenses were defrayed by a grant from the National Institutes of Health (R01DK082623) (to AVT). 56 Current biology ltd; 84 theobalds rd, london wc1x 8rr, england 663dx