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Lee SY , Stadanlick J , Kappes DJ , Wiest DL
Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice
Semin Immunol. 2010 Aug;22(4) :237-46
PMID: 20471282 PMCID: PMC2906684
AbstractWhile insights into the molecular processes that specify adoption of the alphabeta and gammadelta fates are beginning to emerge, the basis for control of specification remains highly controversial. This review highlights the current models attempting to explain T lineage commitment. Recent observations support the hypothesis that the T cell receptor (TCR) provides instructive cues through differences in TCR signaling intensity and/or longevity. Accordingly, we review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates.
NotesLee, Sang-Yun Stadanlick, Jason Kappes, Dietmar J Wiest, David L AI073920/AI/NIAID NIH HHS/United States AI081814/AI/NIAID NIH HHS/United States P01CA06927/CA/NCI NIH HHS/United States P30-DK-50306/DK/NIDDK NIH HHS/United States T32 CA009035/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England Seminars in immunology Semin Immunol. 2010 Aug;22(4):237-46. Epub 2010 May 14.