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Yip SC , Saha S , Chernoff J
PTP1B: a double agent in metabolism and oncogenesis
Trends in Biochemical Sciences. 2010 Aug;35(8) :442-449
AbstractPTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.
NotesYip, Shu-Chin Saha, Sayanti Chernoff, Jonathan Elsevier science london London 641of