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O'Donnell LA , Rall GF
Blue Moon Neurovirology: The Merits of Studying Rare CNS Diseases of Viral Origin
Journal of Neuroimmune Pharmacology. 2010 Sep;5(3) :443-455
AbstractWhile measles virus (MV) continues to have a significant impact on human health, causing 150,000-200,000 deaths worldwide each year, the number of fatalities that can be attributed to MV-triggered central nervous system (CNS) diseases are on the order of a few hundred individuals annually (World Health Organization 2009). Despite this modest impact, substantial effort has been expended to understand the basis of measles-triggered neuropathogenesis. What can be gained by studying such a rare condition? Simply stated, the wealth of studies in this field have revealed core principles that are relevant to multiple neurotropic pathogens, and that inform the broader field of viral pathogenesis. In recent years, the emergence of powerful in vitro systems, novel animal models, and reverse genetics has enabled insights into the basis of MV persistence, the complexity of MV interactions with neurons and the immune system, and the role of immune and CNS development in virus-triggered disease. In this review, we highlight some key advances, link relevant measles-based studies to the broader disciplines of neurovirology and viral pathogenesis, and propose future areas of study for the field of measles-mediated neurological disease.
NotesO'Donnell, Lauren A. Rall, Glenn F. NIH [RO1-NS40500, RO1-NS060701, P30-CA006927]; Autism Speaks ; Pennsylvania Department of Health ; NINDS We thank Kevin O'Regan, Christine Matullo, and Sarah Cavanaugh for advice on this manuscript and acknowledge support from the following sources: G.F.R. was supported by NIH grants RO1-NS40500, RO1-NS060701, P30-CA006927, a Pilot Project grant from Autism Speaks, Pennsylvania Department of Health Tobacco funds, and a gift from the F. M. Kirby Foundation. L.O'D. was supported by an NRSA Postdoctoral fellowship from NINDS. 105 Springer; 233 spring st, new york, ny 10013 usa 634qj