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Hanks GE , Hanlon AL , Schultheiss TE , Freedman GM , Hunt M , Pinover WH , Movsas B
Conformal external beam treatment of prostate cancer
Urology. 1997 Jul;50(1) :87-92
AbstractObjectives. This study reports the 5-year outcomes of treatment for patients with prostate cancer treated largely with conformal three-dimensional radiation therapy. Methods. Results are presented for 456 consecutive patients treated prior to December 31, 1993 whose pretreatment prostate-specific antigen (PSA) levels are known. Biochemical failure was defined as two consecutive rises in the PSA that equals or exceeds 1.5 ng/mL. Kaplan-Meier product limit methods, the log-rank test, and Cox regression models were used in evaluating the data. No patient was lost to follow-up. Results. The 5-year biochemically free of failure (bNED) rate for all patients was 61% and 57% at 7 years. In the group with pretreatment PSA less than 10 ng/mL, the 5-year bNED rate for patients with localized disease (T1,2AB disease, Gleason sum of 6 or less) was 85% and for those with locally advanced disease (T2C,3), 70%. In the group with pretreatment PSA of 10 to 19.9 ng/mL, the 5-year bNED rate for patients with localized disease was 66% and for those with locally advanced disease, 44%. in the group with pretreatment PSA of 20 ng/mL or above, the patients with localized: or locally advanced disease had 5-year bNED rates of 31% and 21%, respectively. Conclusions. The results of largely conformal three-dimensional external beam treatment of localized prostate cancer produced 5-year bNED results that are comparable to recent reports of nerve-sparing prostatectomy. Preliminary 7- year bNED results in all patients and in patients with localized tumors indicated a modest decrease in the cancer-free rate from that observed at 5 years, suggesting the results are durable. (C) 1997, Elsevier Science Inc. All rights reserved.
NotesTimes Cited: 37 English Article XJ076 UROLOGY