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Taylor J , Pelchat M
Origin of hepatitis delta virus
Future Microbiol. 2010 Mar;5(3) :393-402
PMID: 20210550    PMCID: PMC2852136   
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This article addresses some of the questions relating to how hepatitis delta virus (HDV), an agent so far unique in the animal world, might have arisen. HDV was discovered in patients infected with hepatitis B virus (HBV). It generally makes HBV infections more damaging to the liver. It is a subviral satellite agent that depends upon HBV envelope proteins for its assembly and ability to infect new cells. In other aspects of replication, HDV is both independent of and very different from HBV. In addition, the small single-stranded circular RNA genome of HDV, and its mechanism of replication, demonstrate an increasing number of similarities to the viroids - a large family of helper-independent subviral agents that cause pathogenesis in plants.
Taylor, John Pelchat, Martin AI-256522/AI/NIAID NIH HHS/United States CA-06927/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England Future microbiology Future Microbiol. 2010 Mar;5(3):393-402.