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Fernandez SV , Russo J
Estrogen and xenoestrogens in breast cancer
Toxicol Pathol. 2010 ;38(1) :110-22
PMID: 19933552    PMCID: PMC2907875   
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There is growing concern that estrogenic environmental compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fueled by evidence indicating that natural estrogens, specifically 17beta-estradiol, are important factors in the initiation and progression of breast cancer. We have developed an in vitro-in vivo model in which we have demonstrated the carcinogenicity of E2 in human breast epithelial cells MCF-10F. Hypermethylation of NRG1, STXBP6, BMP6, CSS3, SPRY1, and SNIP were found at different progression stages in this model. The use of this powerful and unique model has provided a tool for exploring whether bisphenol A and butyl benzyl phthalate have relevance in the initiation of breast cancer. These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells.
Fernandez, S V Russo, J R21 ES015894/ES/NIEHS NIH HHS/United States U01 ES/CA 12771/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Review United States Toxicologic pathology Toxicol Pathol. 2010;38(1):110-22. Epub 2009 Nov 21.