This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Fernandez SV , Russo J
Estrogen and xenoestrogens in breast cancer
Toxicol Pathol. 2010 ;38(1) :110-22
PMID: 19933552 PMCID: PMC2907875
AbstractThere is growing concern that estrogenic environmental compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fueled by evidence indicating that natural estrogens, specifically 17beta-estradiol, are important factors in the initiation and progression of breast cancer. We have developed an in vitro-in vivo model in which we have demonstrated the carcinogenicity of E2 in human breast epithelial cells MCF-10F. Hypermethylation of NRG1, STXBP6, BMP6, CSS3, SPRY1, and SNIP were found at different progression stages in this model. The use of this powerful and unique model has provided a tool for exploring whether bisphenol A and butyl benzyl phthalate have relevance in the initiation of breast cancer. These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells.
NotesFernandez, S V Russo, J R21 ES015894/ES/NIEHS NIH HHS/United States U01 ES/CA 12771/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Review United States Toxicologic pathology Toxicol Pathol. 2010;38(1):110-22. Epub 2009 Nov 21.