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Sharma NK , Cohen RJ , Eade TN , Buyyounouski MK , Uzzo RG , Li JS , Crawford K , Chen DYT , McNeeley S , Horwitz EM
An intraoperative real-time sleeved seed technique for permanent prostate brachytherapy
Brachytherapy. 2010 Apr-Jun;9(2) :126-130
PMID: ISI:000277012000005   
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PURPOSE: To describe a novel technique that integrates customized sleeved seed production to reduce seed migration using preloaded needles with real-time intraoperative dosimetric planning for patients treated with iodine-125 (I-125) permanent prostate seed implants. METHODS AND MATERIALS: Customized seed-spacer sequences were calculated for patients in real time based on an intraoperative transrectal ultrasound-guided volume study. Using a Fox Chase Cancer Center modified Best Iodine-125 seed loader (Best Medical, Springfield, VA), the seeds and spacers were inserted into a hollow suture material (sleeve) and then loaded into the implant needles. Needles were placed sequentially under transrectal ultrasound guidance with sagittal plane visualization of the dropped sleeved seeds. RESULTS: This technique was successfully implemented allowing intraoperative planning to be combined with real-time sleeved seed production. CONCLUSIONS: The use of sleeves for seeds combined with real-time intraoperative planning allowed for the intraoperative customization of implants with the practical advantages of linked seeds. (C) 2010 Published by Elsevier Inc. on behalf of American Brachytherapy Society.
Sharma, Navesh K. Cohen, Randi J. Eade, Thomas N. Buyyounouski, Mark K. Uzzo, Robert G. Li, Jinsheng Crawford, Kevin Chen, David Y. T. McNeeley, Shawn Horwitz, Eric M. National Cancer Institute [CA-006927, CA101984-01]; Varian Medical Systems This publication was supported in part by Grants CA-006927 and CA101984-01 from the National Cancer Institute and a grant from Varian Medical Systems. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. There is no other financial conflict of interest to disclose. 27 Elsevier science inc; 360 park ave south, new york, ny 10010-1710 usa 587sd