FCCC LOGO Faculty Publications
Lango MN , Egleston B , Ende K , Feigenberg S , D'Ambrosio DJ , Cohen RB , Ahmad S , Nicolaou N , Ridge JA
IMPACT OF NECK DISSECTION ON LONG-TERM FEEDING TUBE DEPENDENCE IN PATIENTS WITH HEAD AND NECK CANCER TREATED WITH PRIMARY RADIATION OR CHEMORADIATION
Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2010 Mar;32(3) :341-347
PMID: ISI:000275157000010   
Back to previous list
Abstract
Background. The impact of posttreatment neck dissection on prolonged feeding tube dependence in patients with head and neck squamous cell cancer (HNSCC) treated with primary radiation or chemoradiation remains unknown. Methods. We conducted a retrospective cohort study using propensity score adjustment to investigate the effect of neck dissection on prolonged feeding tube dependence. Results. A review of 67 patients with node-positive HNSCC (T1-4N1-3), treated with primary radiation or chemoradiation, with no evidence of tumor recurrence and follow-up of at least 24 months, was performed. Following adjustment for covariates, the relative risk (RR) of feeding tube dependence at 18 months was significantly increased in patients treated with posttreatment neck dissection (RR 4.74, 95% confidence interval [CI] 2.07-10.89). At 24 months, the relative risk of feeding tube dependence in the patients having undergone neck dissection increased further (RR 7.66, 95% CI 2.07-10.89). Of patients with feeding tubes 2 years after completing treatment, 75% remained feeding tube dependent. Conclusion. Neck dissection may contribute to chronic oropharyngeal dysphagia in HNSCC patients treated with primary radiation or chemoradiation. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 341-347. 2010
Notes
Lango, Miriam N. Egleston, Brian Ende, Kevin Feigenberg, Steven D'Ambrosio, David J. Cohen, Roger B. Ahmad, Sidrah Nicolaou, Nicos Ridge, John A. Nih [p30 ca 06927] Contract grant sponsor: NIH, contract grant number: P30 CA 06927. 23 John wiley & sons inc; 111 river st, hoboken, nj 07030 usa 563tl