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Pacheco A , Chernoff J
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis
Int J Biochem Cell Biol. 2010 Jan;42(1) :13-6
PMID: 19747561 PMCID: PMC2787825
AbstractGroup I p21-activated kinases are a highly conserved three-member family of serine/threonine kinases that act as key effectors for the small GTPases Cdc42 and Rac. In man, these enzymes have been implicated in a wide range of biological processes and are beginning to draw the attention of the pharmaceutical industry as potential therapeutic targets in cancer and in inflammatory processes. In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection.
NotesPacheco, Almudena Chernoff, Jonathan Review Netherlands The international journal of biochemistry & cell biology Int J Biochem Cell Biol. 2010 Jan;42(1):13-6. Epub 2009 Sep 9.