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Tseng M , Giri V , Watkins-Bruner D , Giovannucci E
Dairy intake and 1,25-dihydroxyvitamin D levels in men at high risk for prostate cancer
Cancer Causes & Control. 2009 Dec;20(10) :1947-1954
PMID: ISI:000271809000016    PMCID: PMC 2895954   
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Abstract
Dairy food intake has been associated with prostate cancer in previous work, but the mechanism by which this occurs is unknown. Dairy calcium may suppress circulating levels of potentially cancer-protective 1,25-hydroxyvitamin D (1,25(OH)(2)D). We examined the associations of dairy, milk, calcium, and vitamin D intake with plasma 1,25(OH)(2)D levels among 296 men (194 black, 102 non-black) enrolled in a high risk program for prostate cancer from 10/96 to 10/07. All participants completed diet and health history questionnaires and provided plasma samples, which were assessed for levels of 25-hydroxyvitamin D and 1,25(OH)(2)D. We used multivariate linear regression to examine associations with 1,25(OH)(2)D. After adjustment for age, race, energy intake, BMI, and alcohol intake, we observed no associations for any of our variables of interest with 1,25(OH)(2)D, or any meaningful differences in estimates by race or vitamin D status. Our findings, in a sample including a large proportion of black participants, do not confirm previous findings showing an inverse association between calcium intake and 1,25(OH)(2)D levels. As such, they suggest that future work should explore other mechanisms by which dairy foods and calcium might increase prostate cancer risk.
Notes
Tseng, Marilyn Giri, Veda Watkins-Bruner, Deborah Giovannucci, Edward National Institutes of Health [R03 CA110892, P30 CA006927] The authors thank the participants of the Prostate Cancer Risk Assessment Program at Fox Chase Cancer Center. We also thank Ms. Susan Raysor and Ms. JoEllen Weaver for their assistance in making the necessary datasets and samples available from the Prostate Cancer Risk Assessment Program; Dr. Cynthia Spittle for her assistance in facilitating transport of samples for vitamin D assays; and Dr. Mustafa Dosemeci for sharing his indices on residential and occupational sunlight exposure. Supported by grants R03 CA110892 and P30 CA006927 from the National Institutes of Health. 38 Springer; van godewijckstraat 30, 3311 gz dordrecht, netherlands 519zh