This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Uzzo RG , Haas NB , Crispen PL , Kolenko VM
Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer
Cancer. 2008 Apr 15;112(8) :1660-71
AbstractNew therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.
NotesUzzo, Robert G Haas, Naomi B Crispen, Paul L Kolenko, Vladimir M R01 CA108890/CA/NCI NIH HHS/United States Research Support, N.I.H., Extramural Review United States Cancer Cancer. 2008 Apr 15;112(8):1660-71.