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Baffoe-Bonnie AB , Kittles RA , Gillanders E , Ou L , George A , Robbins C , Ahaghotu C , Bennett J , Boykin W , Hoke G , Mason T , Pettaway C , Vijayakumar S , Weinrich S , Jones MP , Gildea D , Riedesel E , Albertus J , Moses T , Lockwood E , Klaric M , Faruque M , Royal C , Trent JM , Berg K , Collins FS , Furbert-Harris PM , Bailey-Wilson JE , Dunston GM , Powell I , Carpten JD
Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC)
Prostate. 2007 Jan 1;67(1) :22-31
AbstractBACKGROUND: The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected. METHODS: We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS: Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS: These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.
NotesBaffoe-Bonnie, Agnes B Kittles, Rick A Gillanders, Elizabeth Ou, Liang George, Asha Robbins, Christiane Ahaghotu, Chiledum Bennett, James Boykin, William Hoke, Gerald Mason, Terry Pettaway, Curtis Vijayakumar, Srinivasan Weinrich, Sally Jones, Mary P Gildea, Derek Riedesel, Erica Albertus, Julie Moses, Tracy Lockwood, Erica Klaric, Meghan Faruque, Mezbah Royal, Charmaine Trent, Jeffrey M Berg, Kate Collins, Francis S Furbert-Harris, Paulette M Bailey-Wilson, Joan E Dunston, Georgia M Powell, Isaac Carpten, John D CA-06927/CA/NCI NIH HHS/United States N01-HG-75418/HG/NHGRI NIH HHS/United States RR03048/RR/NCRR NIH HHS/United States Comparative Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural United States The Prostate Prostate. 2007 Jan 1;67(1):22-31.