FCCC LOGO Faculty Publications
Bellacosa A , Lazo PA , Bear SE , Shinton S , Tsichlis PN
Induction of multiple independent T-cell lymphomas in rats inoculated with MOloney murine leukemia virus
Proc Natl Acad Sci U S A. 1989 Jun;86(11) :4269-72
PMID: 2786211    PMCID: PMC287432   
Back to previous list
Tumor cell DNA derived from different lymphoid organs of 30 rats serially inoculated at birth with Moloney murine leukemia virus (MoMuLV) was examined by Southern blot analysis and hybridization to the following DNA probes: MoMuLV long terminal repeat (LTR), Moloney leukemia virus integration regions 1, 2, 3, and 4 (Mlvi-1, Mlvi-2, Mlvi-3, and Mlvi-4), T-cell receptor beta locus, and immunoglobulin heavy chain locus. This analysis revealed that the tumors segregating in different lymphoid organs in 10% of the animals were clonally unrelated. These findings are consistent with the hypothesis that the MoMuLV-induced rat thymic lymphomas are polyclonal in origin. At least two factors may be responsible for this phenomenon: (i) increase in the number of the available target cells in virus-infected animals, and (ii) genetic instability associated with provirus integration in the developing premalignant clones.
Bellacosa, A Lazo, P A Bear, S E Shinton, S Tsichlis, P N CA-06927/CA/NCI NIH HHS/United States CA-38047/CA/NCI NIH HHS/United States CA-43211/CA/NCI NIH HHS/United States etc. Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1989 Jun;86(11):4269-72.