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Cheng JQ , Godwin AK , Bellacosa A , Taguchi T , Franke TF , Hamilton TC , Tsichlis PN , Testa JR
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19) :9267-71
PMID: 1409633 PMCID: PMC50107
AbstractWe isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, this protein contains a Src homology 2-like domain. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. AKT2 was mapped to chromosome region 19q13.1-q13.2 by fluorescence in situ hybridization. In the two ovarian carcinoma cell lines exhibiting amplification of AKT2, the amplified sequences were localized within homogeneously staining regions. We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.
NotesCheng, J Q Godwin, A K Bellacosa, A Taguchi, T Franke, T F Hamilton, T C Tsichlis, P N Testa, J R CA06927/CA/NCI NIH HHS/United States CA38047/CA/NCI NIH HHS/United States RR05895/RR/NCRR NIH HHS/United States etc. Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9267-71.