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Zhang M , Ho A , Hammond EH , Suzuki Y , Bermudez RS , Lee RJ , Pilepich M , Shipley WU , Sandler H , Khor LY , Pollack A , Chakravarti A
Prognostic value of surviving in locally advanced prostate cancer: study based on RTOG 8610
International Journal of Radiation Oncology Biology Physics. 2009 Mar;73(4) :1033-1042
PMID: ISI:000264257400012    PMCID: PMC 2678565   
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Purpose: To examine the prognostic value of nuclear and cytoplasmic survivin expression in men with locally advanced prostate cancer who were enrolled in Radiation Therapy Oncology Group (RTOG) protocol 8610. Methods and Materials: RTOG 8610 was a Phase III randomized study comparing the effect of radiotherapy plus short-term androgen deprivation with radiotherapy alone. Of the 456 eligible patients, 68 patients had suitably stained tumor material for nuclear survivin analysis and 65 patients for cytoplasmic survivin. Results: Compared with patients with nuclear survivin intensity scores of <= 191.2, those with intensity scores >191.2 had significantly improved prostate cancer survival (hazard ratio [HR], 0.45; 95% confidence interval [CI], 0.20-1.00, p = 0.0452). On multivariate analysis, nuclear survivin intensity scores >191.2 were significantly associated with improved overall survival (HR, 0.46; 95% CI, 0.25-0.86; p = 0.0156) and prostate cancer survival (HR, 0.36; 95% CI, 0.16-0.84; p = 0.0173). On univariate analysis, compared with patients with cytoplasmic survivin integrated optical density <= 82.7, those with an integrated optical density >82.7 showed a significantly increased risk of local progression (HR, 2.49; 95% CI, 1.03-6.0 1; p = 0.0421). Conclusion: Nuclear overexpression of survivin was associated with improved overall and prostate cancer survival on multivariate analysis, and cytoplasmic overexpression of survivin was associated with increased rate of local progression on univariate analysis in patients with locally advanced prostate cancer treated on RTOG, 8610. Our results might reflect the different functions of survivin and its splice variants, which are known to exist in distinct subcellular compartments. (C) 2009 Elsevier Inc.
Zhang, Min Ho, Alex Hammond, Elizabeth H. Suzuki, Yoshiyuki Bermudez, R. Scott Lee, R. Jeffrey Pilepich, Michael Shipley, William U. Sandler, Howard Khor, Li-Yan Pollack, Alan Chakravarti, Arnab 50 ELSEVIER SCIENCE INC; 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 419ZE