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Yang DH , Smith ER , Cai KQ , Xu XX
c-fos Elimination Compensates for disabled-2 Requirement in Mouse Extraembryonic Endoderm. Development
Developmental Dynamics. 2009 Mar;238(3) :514-523
PMCID: PMC 2743073   
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Disabled-2 (Dab2) is expressed in primitive endoderm cells as they are differentiating from the inner cell mass and dab2 deficiency in mice results in lethality at E5.5-E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c-Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5.5 dab2 (-/-):c-fos (-/-) embryos, indicating that the primitive endoderm defect due to the loss of Dab2 is rescued by deletion of the c-fos gene. The lethality of the double knockout embryos was delayed until E9.5-E10.5 and the defective embryos failed to undergo organogenesis. We conclude that Dab2 plays a role in epithelial organization by suppression of c-Fos expression and suggest that unsuppressed c-Fos can lead to disruption of primitive endoderm epithelial organization, yet an additional dab2 function is required for later organogenesis. Developmental Dynamics 238:514-523, 2009. (C) 2009 Wiley-Liss, Inc.
Yang, Dong-Hua Smith, Elizabeth R. Cai, Kathy Qi Xu, Xiang-Xi WILEY-LISS 416JE