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Lango MN , Andrews GA , Ahmad S , Feigenberg S , Tuluc M , Gaughan J , Ridge JA
Postradiotherapy neck dissection for head and neck squamous cell carcinoma: pattern of pathological residual carcinoma and prognosis
Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2009 Mar;31(3) :328-337
PMID: ISI:000264011500006   
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Background. For patients with head and neck cancer who were treated using primary radiotherapeutic approaches, the pattern of pathologic residual carcinoma in the neck dissection specimen and its effect on clinical outcome remains unknown. Methods. Medical records of 65 patients who underwent 71 neck dissections a median 7 weeks after radiotherapy were reviewed. Median follow-up was 33 months. Results. Residual cancer, identified in 28 patients (43%), diminished locoregional control (p = .018), recurrence-free (p = .018), and overall survival (p = .02). Thirteen patients (20%,,) had 2 or more pathologically involved lymph nodes. Nine (13%) involved level V. Four (6%) had pathologic involvement of nodal levels not clinically involved by cancer before treatment. In N2-3 patients with positive pathologic specimens, the presence of these factors diminished recurrence-free survival (p = .01). The outcome of patients with pathologic carcinoma but without such ominous factors approached those with negative pathology. Conclusions. For patients with residual carcinoma in the neck following radiation, the pattern of residual disease is an prognosis effective predictor of recurrence. (C) 2008 Wiley Periodicals, Inc. Head Neck 31: 328-337, 2009
Lango, Miriam N. Andrews, Genevieve A. Ahmad, Sidrah Feigenberg, Steven Tuluc, Madalina Gaughan, John Ridge, John A. 27 JOHN WILEY & SONS INC; 111 RIVER ST, HOBOKEN, NJ 07030 USA 416MZ