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Somaiah N , von Mehren M
New therapeutic approaches for advanced gastrointestinal stromal tumors
Hematol Oncol Clin North Am. 2009 Feb;23(1) :139-50
PMID: 19248977 PMCID: PMC2861350
AbstractThe management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.
NotesSomaiah, Neeta von Mehren, Margaret United States Hematology/oncology clinics of North America Hematol Oncol Clin North Am. 2009 Feb;23(1):139-50.