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Xu H , Li H , Suri-Payer E , Hardy RR , Weigert M
Regulation of anti-DNA B cells in recombination-activating gene-deficient mice
Journal of Experimental Medicine. 1998 Oct 5;188(7) :1247-1254
AbstractAnti-DNA antibodies are regulated in normal individuals but are found in high concentration in the serum of systemic lupus erythematosus (SLE) patients and the MRT, lpr/lpr mouse model of SLE. We previously studied the regulation of anti-double- stranded (ds)DNA and anti-single-stranded (ss)DNA B cells in a nonautoimmune background by generating mice carrying immunoglobulin transgenes coding for anti-DNAs derived from MRL lpr/lpr Anti-dsDNA B cells undergo receptor editing, but anti- ssDNA B cells seem to be functionally silenced. Here we have investigated how anti-DNA B cells are regulated in recombination-activating gene (RAG)-2(-/-) mice. In this setting, anti-dsDNA B cells are eliminated by apoptosis in the bone marrow and anti-ssDNA B cells are partially activated.
NotesTimes Cited: 24 English Article 129EL J EXP MED