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von Gegerfelt AS , Rosati M , Alicea C , Valentin A , Roth P , Bear J , Franchini G , Albert PS , Bischofberger N , Boyer JD , Weiner DB , Markham P , Israel ZR , Eldridge JH , Pavlakis GN , Felber BK
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization
Journal of Virology. 2007 Feb;81(4) :1972-9
PMID: 17135321 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17135321
AbstractRhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P = 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy.
Notesvon Gegerfelt, Agneta S Rosati, Margherita Alicea, Candido Valentin, Antonio Roth, Patricia Bear, Jenifer Franchini, Genoveffa Albert, Paul S Bischofberger, Norbert Boyer, Jean D Weiner, David B Markham, Phillip Israel, Zimra R Eldridge, John H Pavlakis, George N Felber, Barbara K Research Support, N.I.H., Intramural United States Journal of virology J Virol. 2007 Feb;81(4):1972-9. Epub 2006 Nov 29.