This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Chang JH , Cruo JT , Jiang D , Guo HT , Taylor JM , Block TM
Liver-specific MicroRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells
Journal of Virology. 2008 Aug;82(16) :8215-8223
AbstractThe liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.
NotesISI Document Delivery No.: 333QF Chang, Jinhong Cruo, Ju-Tao Jiang, Dong Guo, Haitao Taylor, John M. Block, Timothy M. AMER SOC MICROBIOLOGY