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Chang JH , Cruo JT , Jiang D , Guo HT , Taylor JM , Block TM
Liver-specific MicroRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells
Journal of Virology. 2008 Aug;82(16) :8215-8223
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The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.
ISI Document Delivery No.: 333QF Chang, Jinhong Cruo, Ju-Tao Jiang, Dong Guo, Haitao Taylor, John M. Block, Timothy M. AMER SOC MICROBIOLOGY