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Zaret Kenneth S
Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
Nature Reviews Genetics. 2008 ;9(5) :329-340
PMID: AN 2008:487215   
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Abstract
A review. Newly specified hepatic and pancreatic progenitors, which originate from common endodermal domains, are able to reverse their course and develop into gut progenitors. Understanding what underlies such programming reversal and intrinsic regenerative capacities should illuminate the basis of cellular plasticity and facilitate targeted programming of stem cells. The liver and pancreas arise from a common multi-potent population of endoderm cells and share many aspects of their early development. Yet each tissue originates from multiple spatial domains of the endoderm, under the influence of different genes and inductive cues, and obtains different regenerative capacities. Emerging genetic evidence is illuminating the ability of newly specified hepatic and pancreatic progenitors to reverse their course and develop into gut progenitors. Understanding how tissue programming can be reversed and how intrinsic regenerative capacities are detd. should facilitate the discovery of the basis of cellular plasticity and aid in the targeted programming and growth of stem cells. [on SciFinder (R)]
Notes
CAN 148:513796 13-0 Mammalian Biochemistry Epigenetics and Progenitor Cells Program,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal; General Review 1471-0056