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Pugacheva EN , Roegiers F , Golemis EA
Interdependence of cell attachment and cell cycle signaling
Curr Opin Cell Biol. 2006 Oct;18(5) :507-15
PMID: 16919436 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16919436
AbstractAdult metazoans represent the culmination of an intricate developmental process involving the temporally and spatially orchestrated division, migration, differentiation, attachment, polarization and death of individual cells. An elaborate infrastructure connecting the cell cycle and cell attachment machinery is essential for such exquisite integration of developmental processes. Integrin-, cadherin-, Merlin- and planar cell polarity (PCP)-dependent signaling cascades quantitatively and qualitatively program cell division during development. Proteins in this signaling infrastructure may represent an important source of cancer vulnerability in metazoans, as their dysfunction can pleiotropically promote the oncogenic process.
NotesPugacheva, Elena N Roegiers, Fabrice Golemis, Erica A CA-06927/CA/United States NCI CA63366/CA/United States NCI Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review United States Current opinion in cell biology Curr Opin Cell Biol. 2006 Oct;18(5):507-15. Epub 2006 Aug 17.