FCCC LOGO Faculty Publications
Adams PD
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
Gene. 2007 Aug 1;397(1-2) :84-93
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Cellular senescence is an important tumor suppression process, and a possible contributor to tissue aging. Senescence is accompanied by extensive changes in chromatin structure. In particular, many senescent cells accumulate specialized domains of facultative heterochromatin, called Senescence-Associated Heterochromatin Foci (SAHF), which are thought to repress expression of proliferation-promoting genes, thereby contributing to senescence-associated proliferation arrest. This article reviews our current understanding of the structure, assembly and function of these SAHF at a cellular level. The possible contribution of SAHF to tumor suppression and tissue aging is also critically discussed.
Adams, Peter D Review Netherlands Gene Gene. 2007 Aug 1;397(1-2):84-93. Epub 2007 May 1.