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Sauter ER , Ganz PA , Ehya H , Hewett JE , Schlatter L , Kliethermes B , Daly MB
Prospective multicenter trial to determine the feasibility of collection and predictive ability of breast fluid analysis in postmenopausal women receiving SERMs
Breast. 2007 Oct;16(5) :489-494
PMID: ISI:000257274100009   
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Abstract
We conducted a prospective ancillary study to the study of tamoxifen and raloxifene (STAR) trial involving 4 institutions to determine: (1) our ability to collect nipple aspirate fluid (NAF) in postmenopausal women taking medication to decrease breast proliferation and (2) NAF biomarkers associated with breast cancer. NAF was collected before and 6 months after starting treatment. Three biomarkers, cytology, fluid volume, and prostate-specific antigen (PSA), were analyzed. NAF was collected from 26 of 33 (79%) enrolled subjects at baseline. We were able to collect fluid in 84% of the subjects who produced NAF at baseline and returned for second aspiration after 6 months of treatment. In these women, cytology was unchanged in 85%, improved in 11%, and worsened in 4% of breasts. Median PSA increased from 37.5 to 112 ng/L after treatment. NAF volume did not significantly change. In conclusion, after treatment with tamoxifen or ratoxifene, changes in both NAF cytology and PSA were generally favorable, consistent with their expected antiproliferative effective effect on the breast. Multiinstitutional clinical trials in postmenopausal women using NAF biomarkers as the primary endpoints are feasible. (c) 2007 Elsevier Ltd. All rights reserved.
Notes
ISI Document Delivery No.: 320ZP Times Cited: 0 Cited Reference Count: 10 Cited References: FISHER B, 1998, J NATL CANCER I, V90, P1371 KING EB, 1983, J NATL CANCER I, V71, P1115 PETRAKIS NL, 1975, J NATL CANCER I, V54, P829 PETRAKIS NL, 1993, CANCER EPIDEM BIOMAR, V2, P3 PETRAKIS NL, 1996, CANCER EPIDEM BIOMAR, V5, P785 SAUTER ER, 1996, CANCER EPIDEM BIOMAR, V5, P967 SAUTER ER, 1997, BRIT J CANCER, V76, P494 SAUTER ER, 2004, CANCER DETECT PREV, V28, P27 SAUTER ER, 2004, INT J CANCER, V108, P588 WRENSCH MR, 2001, J NATL CANCER I, V93, P1791 Sauter, Edward R. Ganz, Patricia A. Ehya, Hormoz Hewett, John E. Schlatter, Lisa Kliethermes, Beth Daly, Mary B. CHURCHILL LIVINGSTONE; JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND