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Osteonecrosis of the jaw, a recently recognized sequela of bisphosphonate therapy: case report
Support Cancer Ther. 2006 Jan 1;3(2) :122-4
AbstractIn the oncologic setting, osteonecrosis, which generally occurs after a temporary or permanent loss of blood supply to the bones, is frequently caused by radiation or combined chemoradiation therapy, particularly in head and neck cancers. However, this well-recognized phenomenon remains relatively rare. Recently, cases of osteonecrosis of the jaw have been reported over a 2-year period, with the majority occuring in oncology patients, the only commonality being the use of bisphosphonate therapy. Herein, we report a patient with breast carcinoma metastatic to bone that developed osteonecrosis that ultimately resolved with supportive measures. She was successfully rechallenged with bisphosphates without recurrence or sequelae.
NotesLanger, Corey J United States Supportive cancer therapy Support Cancer Ther. 2006 Jan 1;3(2):122-4.