FCCC LOGO Faculty Publications
Block TM , Marrero J , Gish RG , Sherman M , London WT , Srivastava S , Wagner PD
The degree of readiness of selected biomarkers for the early detection of hepatocellular carcinoma: Notes from a recent workshop
Cancer Biomarkers. 2008 ;4(1) :19-33
PMID: ISI:000256067300003   
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This opinion piece evaluates the degree of readiness of 13 candidate biomarkers or panels of biomarkers for the early detection of hepatocellular carcinoma (HCC), or for the staging of liver fibrosis. As candidate biomarkers for the early detection of disease are identified, it is important to understand where they are in the developmental pipeline and how they might be employed. HCC is a growing public health problem, and its early detection is believed to be important in its management. Current detection methods are limited in usefulness or practicality, and there is a need for better methods to diagnose liver disease. Therefore, a number of candidate biomarkers, considered to be attractive because of their advanced stage of development or inherent scientific value, were evaluated for specificity and sensitivity for detection of liver disease. Study design, confirmatory evidence and assay practicality associated with each of the biomarkers are considered. The comments in this review reflect the authors' opinions and are based on a recent workshop convened by the Hepatitis B Foundation of America and the US National Cancer Institute's Early Detection Research Network. It is emphasized that only a selected set of biomarkers was considered; thus, this review is not comprehensive and not intended to review all candidate HCC biomarkers.
ISI Document Delivery No.: 303UV Times Cited: 0 Cited Reference Count: 59 Cited References: ALPERT ME, 1968, NEW ENGL J MED, V278, P984 ANNES JP, 2003, J CELL SCI, V116, P217 AOYAGI Y, 1995, GLYCOCONJUGATE J, V12, P194 AOYAGI Y, 1998, CANCER, V83, P2076 BLOCK TM, 2003, ONCOGENE, V22, P5093 BLOCK TM, 2005, P NATL ACAD SCI USA, V102, P779 BRECHOT C, 1987, J HEPATOL, V4, P269 BRUIX J, 2005, HEPATOLOGY, V42, P1208 BUAMAH PK, 1984, CLIN CHIM ACTA, V139, P313 CALLEWAERT N, 2004, NAT MED, V10, P429 CAPURRO M, 2003, GASTROENTEROLOGY, V125, P89 CHEN BF, 2006, GASTROENTEROLOGY, V130, P1153 CHEN G, 2006, AM J GASTROENTEROL, V101, P1797 CHEN X, 2002, MOL BIOL CELL, V13, P1929 CHEUNG ST, 2004, CLIN CANCER RES, V10, P7629 ELSERAG HB, 1999, NEW ENGL J MED, V340, P745 EVANS AA, 1998, CANCER EPIDEM BIOMAR, V7, P559 FAN YF, 2001, HEPATOLOGY, V33, P277 FURUKAWA K, 1992, CURR OPIN BIOTECH, V3, P554 GERKEN G, 1991, VIROLOGY, V183, P555 HALFON P, 2002, J CLIN MICROBIOL, V40, P1541 HIPPO Y, 2004, CANCER RES, V64, P2418 HOOFNAGLE JH, 1997, NEW ENGL J MED, V336, P347 IMBERTBISMUT F, 2001, LANCET, V357, P1069 ITO N, 1991, CANCER RES, V51, P4080 KAO JH, 2003, GASTROENTEROLOGY, V124, P327 KAUL V, 2002, AM J GASTROENTEROL, V97, P2623 KLADNEY RD, 2002, HEPATOLOGY, V35, P1431 KUANG SY, 2004, P NATL ACAD SCI USA, V101, P3572 LIN CL, 2005, LIVER INT, V25, P564 LOK AS, 2000, GASTROENTEROLOGY, V122, P2092 LOK ASF, 2001, HEPATOLOGY, V34, P1225 LUK JM, 2006, PROTEOMICS, V6, P1049 LUO JH, 2006, HEPATOLOGY, V44, P1012 MARRERO JA, 2003, HEPATOLOGY, V37, P1114 MARRERO JA, 2005, LIVER TRANSPLANT, V11, P281 MARRERO JA, 2006, CURR OPIN GASTROEN, V22, P248 MCGLYNN KA, 2005, BEST PRACT RES CL GA, V19, P3 MCMAHON BJ, 2000, HEPATOLOGY 1, V32, P842 NAKATSURA T, 2003, BIOCHEM BIOPH RES CO, V306, P16 OKAMOTO H, 1987, JPN J EXP MED, V57, P217 PEPE MS, 2001, J NATL CANCER I, V93, P1054 POYNARD T, 1997, J VIRAL HEPATITIS, V4, P199 SANTANTONIO T, 1992, VIROLOGY, V188, P948 SHERMAN M, 2001, SEMIN ONCOL, V28, P450 SONG HH, 2002, BBA-GEN SUBJECTS, V1573, P241 STEEL LF, 2001, DIS MARKERS, V17, P179 SUGAUCHI F, 2003, J MED VIROL, V70 TAI PC, 2002, VIROLOGY, V292, P44 THORGEIRSSON SS, 2002, NAT GENET, V31, P339 TSAI JF, 2003, TUMOR BIOL, V24, P291 UEMURA M, 2003, CANCER, V97, P2474 WANG HC, 2005, HEPATOLOGY, V41, P761 WANG XC, 2005, P NATL ACAD SCI USA, V102, P15791 WANG XY, 2006, HUM PATHOL, V37, P1435 WEITZ IC, 1993, HEPATOLOGY, V18, P990 YAMAUCHI N, 2005, MODERN PATHOL, V18, P1591 YU MW, 2005, J NATL CANCER I, V97, P265 ZHU ZW, 2001, GUT, V48, P558 Block, Timothy M. Marrero, Jorge Gish, Robert G. Sherman, Morris London, W. Thomas Srivastava, Sudhir Wagner, Paul D. IOS PRESS; NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS