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Zeechini S , Bianchi M , Colombo N , Fasani R , Goisis G , Casadio C , Viale G , Liu J , Herlyn M , Godwin AK , Nuciforo PG , Cavallaro U
The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium
Cancer Research. 2008 Feb;68(4) :1110-1118
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Epithelial ovarian carcinoma (EOC) arises from the ovarian surface epithelium (OSE), a monolayer of poorly differentiated epithelial cells that lines the ovary. The molecular mechanisms underlying EOC invasion into the surrounding stroma and dissemination to the peritoneum and to retroperitoneal lymph nodes are still unclear. Here, we analyzed the expression and the functional role of the cell adhesion molecule L1 during EOC development. In patient-derived samples, L1 was expressed both in OSE and in a subset of EOC, in the latter being mostly restricted to the invasive areas of the tumors. The expression of L1 correlated significantly with poor outcome and with unfavorable clinicopathologic features of the disease. The peculiar expression pattern of L1 in normal OSE and invasive EOC raised the possibility that this adhesion molecule serves a different function in nontransformed versus neoplastic ovarian epithelial cells. Indeed, we showed that in OSE cells L1 supports ce!
ISI Document Delivery No.: 263YH Zeechini, Silvia Bianchi, Marco Colombo, Nicoletta Fasani, Roberta Goisis, Giovanni Casadio, Chiara Viale, Giuseppe Liu, Jinsong Herlyn, Meenhard Godwin, Andrew K. Nuciforo, Paolo G. Cavallaro, Ugo AMER ASSOC CANCER RESEARCH