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Cantor SB , Cardenas-Turanzas M , Cox DD , Atkinson EN , Nogueras-Gonzalez GM , Beck JR , Follen M , Benedet JL
Accuracy of colposcopy in the diagnostic setting compared with the screening setting
Obstetrics and Gynecology. 2008 Jan;111(1) :7-14
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OBJECTIVE: To estimate the accuracy of colposcopy to identify cervical precancer in screening and diagnostic settings. METHODS: As part of a larger clinical trial to evaluate the diagnostic accuracy of optical spectroscopy, we recruited 1,850 patients into a diagnostic or a screening group depending on their history of abnormal findings on Papanicolaou tests. Colposcopic examinations were performed and biopsies specimens obtained from abnormal and normal colposcopic sites for all patients. The criterion standard of test accuracy was the histologic report of biopsies. We calculated sensitivities, specificities, likelihood ratios, receiver operating characteristic curves, and areas under the receiver operating characteristic curves. RESULTS: The prevalence of high-grade squamous intraepithelial lesions (HSIL) or cancer was 29.0% for the diagnostic group and 2.2% for the screening group. Using a disease threshold of HSIL, colposcopy had a sensitivity of 0.983 and a specifici!
Cantor, Scott B. Cardenas-Turanzas, Marylou Cox, Dennis D. Atkinson, E. Neely Nogueras-Gonzalez, Graciela M. Beck, J. Robert Follen, Michele Benedet, J. L. LIPPINCOTT WILLIAMS & WILKINS