FCCC LOGO Faculty Publications
Khazak V , Astsaturov I , Serebriiskii IG , Golemis EA
Selective Raf inhibition in cancer therapy
Expert Opinion on Therapeutic Targets. 2007 Dec;11(12) :1587-1609
PMID: ISI:000251556000006   
Back to previous list
Over the past 5 years, the Raf kinase family has emerged as a promising target for protein-directed cancer therapy development. The goal of this review is to first provide a concise summary of the data validating Raf proteins as high-interest therapeutic targets. The authors then outline the mode of action of Raf kinases, emphasizing how Raf activities and protein interactions suggest specific approaches to inhibiting Raf. The authors then summarize the set of drugs, antisense reagents and antibodies available or in development for therapeutically targeting Raf or Raf-related proteins, as well as existing strategies combining these and other therapeutic agents. Finally, the authors discuss recent results from systems biology analyses that have the potential to increasingly guide the intelligent selection of combination therapies involving Raf-targeting agents and other therapeutics.
ISI Document Delivery No.: 239ZE Times Cited: 0 Cited Reference Count: 216 Cited References: ABOUALFA GK, 2006, J CLIN ONCOL, V24, P4293 ABROSIMOV A, 2007, INT J CANCER, V120, P196 ADJEI AA, 2005, CLIN LUNG CANCER, V7, P221 ADNANE L, 2005, AM ASS CANC RES NATL ALAVI AS, 2007, CANCER RES, V67, P2766 AMIRI P, 2006, AACR 97 M WASH DC US ASTSATUROV I, 2006, EXPERT REV ANTICANC, V6, P1179 ATADJA P, 2004, CANCER RES, V64, P689 AUST DE, 2005, INT J CANCER, V115, P673 BABA I, 2000, CANCER RES, V60, P6886 BALI P, 2005, J BIOL CHEM, V280, P26729 BANDYOPADHYAY S, 2006, GENOME RES, V16, P428 BARNES CJ, 2007, CLIN CANCER RES, V13, P4291 BASTO D, 2005, ACTA NEUROPATHOL, V109, P207 BEERAM M, 2005, J CLIN ONCOL, V23, P6771 BENEVENUTI S, 2007, CANCER RES, V67, P2643 BERGER DH, 1997, J SURG RES, V69, P199 BRITTEN RA, 2000, ONCOL REP, V7, P821 BROSE MS, 2002, CANCER RES, V62, P6997 BURTNESS B, 2007, EXPERT OPIN BIOL TH, V7, P823 CALLANS LS, 1995, ANN SURG ONCOL, V2, P38 CAMPBELL PM, 2007, CANCER RES, V67, P2098 CARAGLIA M, 2003, CELL DEATH DIFFER, V10, P218 CARAGLIA M, 2006, ANN ONCOL, V17, P124 CARAGLIA M, 2007, INT J CANCER, V121, P2317 CARLOMAGNO E, 2006, J NATL CANCER I, V98, P326 CHANG YS, 2007, CANCER CHEMOTH PHARM, V59, P561 CHEN J, 2001, P NATL ACAD SCI USA, V98, P7783 CHRISTIANSEN DH, 2005, LEUKEMIA, V19, P2232 COUDERT B, 2001, EUR J CANCER, V37, P2194 CRIPPS MC, 2002, CLIN CANCER RES, V8, P2188 CUNNINGHAM CC, 2000, CLIN CANCER RES, V6, P1626 DADAMO DR, 2007, ASCO M ABSTR S, V25, P10001 DASGUPTA P, 2004, MOL CELL BIOL, V24, P9527 DAVIES H, 2002, NATURE, V417, P949 DAVIES SP, 2000, BIOCHEM J 1, V351, P95 DRITSCHILO A, 2006, CLIN CANCER RES, V12, P1251 DUVIC M, 2007, BLOOD, V109, P31 EBERHARD DA, 2005, J CLIN ONCOL, V23, P5900 EDDY SR, 2006, SCIENCE, V311, P1381 EDLUNDHROSE E, 2006, MELONOMA RES, V166, P471 EDWARDS LA, 2006, MOL CANCER THER, V5, P645 EHRENREITER K, 2005, J CELL BIOL, V168, P955 EISEN T, 2006, BRIT J CANCER, V95, P581 EMUSS V, 2005, CANCER RES, V65, P9719 ESCUDIER B, 2007, NEW ENGL J MED, V356, P125 FABIAN MA, 2005, NAT BIOTECHNOL, V23, P329 FECHER LA, 2007, J CLIN ONCOL, V25, P1606 FLAVIN R, 2007, INT J SURG PATHOL, V15, P116 FORBES S, 2006, BRIT J CANCER, V94, P318 FORD S, 2007, AACR ANN M FRANSEN K, 2004, CARCINOGENESIS, V25, P527 FRIESS T, 2005, CLIN CANCER RES, V11, P5300 FUHRMANN G, 2001, ONCOGENE, V20, P4542 GALABOVAKOVACS G, 2006, CELL CYCLE, V5, P1514 GALAKTIONOV K, 1995, GENE DEV, V9, P1046 GALMICHE A, 2006, BIOCH BIOPHYS ACTA GANDHI TKB, 2006, NAT GENET, V38, P285 GARNETT MJ, 2005, MOL CELL, V20, P963 GATZEMEIER U, 2006, J CLIN ONCOL, V24, P7002 GEIGER T, 1997, CLIN CANCER RES, V3, P1179 GIROUX S, 1999, CURR BIOL, V9, P369 GOH KI, 2007, P NATL ACAD SCI USA, V104, P8685 GOKHALE PC, 1999, ANTISENSE NUCLEIC A, V9, P191 GOKHALE PC, 2002, CLIN CANCER RES, V8, P3611 GOLLOB JA, 2007, J CLIN ONCOL, V25, P3288 GRAVALOS C, 2007, ASCO M ABSTR S, V25, P4120 GRAZIANO SL, 1991, GENE CHROMOSOME CANC, V3, P283 GRBOVIC OM, 2006, P NATL ACAD SCI USA, V103, P57 GUPTA K, 1999, EXP CELL RES, V247, P495 GUPTA V, 2007, ASCO M ABSTR S, V25, P6019 GUSTAFSSON B, 2005, LEUKEMIA, V19, P310 HALLJACKSON CA, 1999, CHEM BIOL, V6, P559 HAUGHN L, 2003, J BIOL CHEM, V278, P25158 HEATH EI, 2005, CLIN PROSTATE CANC, V4, P138 HEIDECKER G, 1990, MOL CELL BIOL, V10, P2503 HIDESHIMA T, 2005, P NATL ACAD SCI USA, V102, P8567 HINGORANI SR, 2003, CANCER RES, V63, P5198 HJELMELAND AB, 2007, MOL CANCER THER, V6, P2449 HOOD JD, 2002, SCIENCE, V296, P2404 HOOD JD, 2003, J CELL BIOL, V162, P933 HOUBEN R, 2007, J INVEST DERMATOL, V127, P2116 HUANG SM, 2004, CANCER RES, V64, P5355 HWANG YH, 2004, HEPATOL RES, V29, P113 IHLE NT, 2005, MOL CANCER THER, V4, P1349 IKEDA S, 1989, JPN J CANCER RES, V80, P6 ILAN N, 1998, J CELL SCI 24, V111, P3621 ISLAM A, 2000, J DRUG TARGET, V7, P373 JANOSCH P, 2000, FASEB J, V14, P2008 JEUKEN J, 2007, ACTA NEUROPATHOL, V114, P121 JIMENO A, 2007, BRIT J CANCER, V96, P952 KAPPES A, 2006, J SURG RES, V133, P42 KASIBHATLA SR, 2007, J MED CHEM, V50, P2767 KASID U, 2003, ONCOGENE, V22, P5876 KATOSTANKIEWICZ J, 2002, P NATL ACAD SCI USA, V99, P14398 KELLEY BP, 2004, NUCLEIC ACIDS RES S2, V32, W83 KERKHOFF E, 2000, CELL GROWTH DIFFER, V11, P185 KIMURA ET, 2003, CANCER RES, V63, P1454 KNOBBE CB, 2004, ACTA NEUROPATHOL, V108, P467 KNOX J, 2007, J CLIN ONCOL, V25, P5011 KOLCH W, 2000, BIOCHEM J 2, V351, P289 KOLCH W, 2005, NAT REV MOL CELL BIO, V6, P827 KORC M, 1992, J CLIN INVEST, V90, P1352 KORSHUNOV A, 2003, AM J PATHOL, V163, P1721 KOVACS JJ, 2005, MOL CELL, V18, P601 KU NO, 2004, J CELL BIOL, V166, P479 KUMAGAI A, 2007, ENDOCR J, V54, P399 KUMAR R, 2005, SEMIN ONCOL S9, V32, S37 LAGE K, 2007, NAT BIOTECHNOL, V25, P309 LAMBERTI A, 2007, CELL DEATH DIFFER, V14, P952 LECHT DT, 2007, BIOCHIM BIOPHYS ACTA, V1773, P1196 LEE JT, 2003, CURR OPIN INVESTIG D, V4, P757 LEE JW, 2003, BRIT J CANCER, V89, P1958 LEE JW, 2004, LEUKEMIA, V18, P170 LEE SH, 2003, ONCOGENE, V22, P6942 LENG QX, 2005, CANCER GENE THER, V12, P682 LI SQ, 2005, CANCER CELL, V7, P301 LIEVRE A, 2006, CANCER RES, V66, P3992 LIM KH, 2005, CANCER CELL, V7, P533 LIM KH, 2006, CURR BIOL, V16, P2385 LIU DX, 2007, J CLIN ENDOCR METAB, V92, P2264 LIU L, 2006, CANCER RES, V66, P11851 LLOVET J, 2007, AM SOC CLIN ONCOL LU YC, 2004, BIOORG MED CHEM LETT, V14, P3957 LYONS JF, 2001, ENDOCR-RELAT CANCER, V8, P219 MAK HC, 2007, NUCLEIC ACIDS RES, V35, D538 MALUMBRES M, 2003, NAT REV CANCER, V3, P459 MAYR D, 2006, GYNECOL ONCOL, V103, P883 MCDERMOTT DF, 2007, ACO M ABSTR S, V25, P8511 MCPHILLIPS F, 2006, CARCINOGENESIS, V27, P729 MEWANI RR, 2004, INT J ONCOL, V24, P1181 MITSIADES CS, 2004, P NATL ACAD SCI USA, V101, P540 MITSIADES CS, 2007, MOL CANCER THER, V6, P1070 MIYATA Y, 2005, CURR PHARM DESIGN, V11, P1131 MOASSER MM, 2007, ONCOGENE, V26, P6469 MOASSER MM, 2007, ONCOGENE, V26, P6577 MOLIFE R, 2007, CLIN CANCER RES, V13, P1068 MONIA BP, 1996, NAT MED, V2, P668 MONIA BP, 1996, P NATL ACAD SCI USA, V93, P15481 MORONI M, 2005, LANCET ONCOL, V6, P279 MOTT HR, 1996, P NATL ACAD SCI USA, V93, P8312 MULLEN P, 2006, INT J CANCER, V118, P1565 MURPHY DA, 2006, AM J PATHOL, V169, P1875 MURPHY PJM, 2005, J BIOL CHEM, V280, P33792 NAGY B, 2007, LEUK RES NECKERS L, 2007, J BIOSCIENCES, V32, P517 NICHOLAS MK, 2006, CLIN CANCER RES, V12, P7261 NIKIFOROVA MN, 2003, J CLIN ENDOCR METAB, V88, P5399 ODWYER PJ, 1999, CLIN CANCER RES, V5, P3977 ONEILL E, 2004, SCIENCE, V306, P2267 ORTON RJ, 2005, BIOCHEM J 2, V392, P249 OUYANG B, 2006, CLIN CANCER RES, V12, P1785 OZA AM, 2003, GYNECOL ONCOL, V89, P129 PAL A, 2005, INT J ONCOL, V26, P1087 PANKA DJ, 2006, CANCER RES, V66, P1611 PAO W, 2005, PLOS MED, V2, P57 PATEL BKR, 1993, MOL CARCINOGEN, V8, P7 PATEL BKR, 1997, MOL CARCINOGEN, V18, P1 PEI J, 2004, ANTI-CANCER DRUG, V15, P243 RAHMANI M, 2005, J BIOL CHEM, V280, P35217 REID A, 2007, EUR J CANCER, V43, P481 RHODES DR, 2005, NAT GENET S, V37, S31 RHODES DR, 2007, NEOPLASIA, V9, P166 RINEHART J, 2004, J CLIN ONCOL, V22, P4456 ROBERTS PJ, 2007, ONCOGENE, V26, P3291 RONNEN EA, 2006, INVEST NEW DRUG, V24, P543 RUDIN CM, 2001, CLIN CANCER RES, V7, P1214 RUDIN CM, 2004, CLIN CANCER RES, V10, P7244 RUSINEK D, 2006, ENDOKRYNOL POL, V57, P438 RYAN CW, 2007, J CLIN ONCOL, V25, P3296 SALA E, 2007, AACR 98 M LOS ANG US SASAO S, 2006, ONCOL REP, V16, P11 SATHORNSUMETEE S, 2006, CANCER RES, V66, P8722 SCHRECK R, 2006, INT J CANCER, V119, P2261 SCHULZE WX, 2005, MOL SYST BIOL, V1 SHADAD FN, 2006, CLIN LYMPHOMA MYELOM, V6, P500 SHANNON P, 2003, GENOME RES, V13, P2498 SHARAN R, 2006, NAT BIOTECHNOL, V24, P427 SHARMA A, 2005, CANCER RES, V65, P2412 SHARMA SV, 2007, NAT REV CANCER, V7, P169 SHAW RJ, 2006, NATURE, V441, P424 SHEN M, 2007, AACR 98 M SIEBEN NLG, 2004, J PATHOL, V202, P336 SJOBLOM T, 2006, SCIENCE, V314, P268 SKOBELEVA N, 2007, MOL CANCER THER, V6, P898 SOLDATENKOV VA, 1997, CANCER J SCI AM, V3, P13 SOLIT DB, 2006, NATURE, V439, P358 SOMMERER F, 2004, ONCOGENE, V23, P554 STEVENSON JP, 1999, J CLIN ONCOL, V17, P2227 STRUMBERG D, 2007, ONCOLOGIST, V12, P426 TANNAPFEL A, 2003, GUT, V52, P706 TERADA T, 1999, J MOL BIOL, V286, P219 TOLCHER AW, 2002, CLIN CANCER RES, V8, P2530 TRAN NH, 2005, J BIOL CHEM, V280, P16244 TSAI J, 2006, AACR 97 M WASH DC US UETZ P, 2006, MOL SYST BIOL, V2 UGUREL S, 2007, PLOS ONE, V2, E236 VANGOMPEL JJ, 2005, MOL CANCER THER, V4, P910 VERONESE ML, 2006, J CLIN ONCOL, V24, P1363 WAN PTC, 2004, CELL, V116, P855 WANG HG, 1996, CELL, V87, P629 WANG HG, 1996, P NATL ACAD SCI USA, V93, P7063 WEBER A, 2003, ONCOGENE, V22, P4757 WEIGEL BJ, 2007, CLIN CANCER RES, V13, P1789 WELLBROCK C, 2004, NAT REV MOL CELL BIO, V5, P875 WILHELM SM, 2004, CANCER RES, V64, P7099 WILLIAMS JG, 2000, J BIOL CHEM, V275, P22172 WILLIAMSON SK, 2007, J CLIN ONCOL S, V25, P6044 WORKMAN P, 2007, IN PRESS ANN NY ACAD YAMANAKA Y, 1992, NIPPON IKA DAIGAKU Z, V59, P51 YEH TC, 2007, CLIN CANCER RES, V13, P1576 YU CR, 2005, ONCOGENE, V24, P6861 YU Y, 1999, J CELL PHYSIOL, V178, P235 ZEBISCH A, 2006, CANCER RES, V66, P3401 ZHONG WW, 2006, SCIENCE, V311, P1481 ZHU WH, 2002, AM J PATHOL, V161, P823 Khazak, Vladimir Astsaturov, Igor Serebriiskii, Ilya G. Golemis, Erica A. INFORMA HEALTHCARE; TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND