FCCC LOGO Faculty Publications
Kappes DJ
CD4 and CD8: Hogging All the Lck
Immunity. 2007 Nov 26;27(5) :691-693
PMID: 18031691   
Back to previous list
Specificity of T cell receptors (TCRs) to major histocompatibility complex (MHC) might be intrinsic or imposed by thymic selection. Van Laethem et al. (2007) propose that the sequestration of the kinase Lck by coreceptors prevents the selection of non-MHC-reactive TCRs.
Immunity. 2007 Nov 26;27(5):691-693.