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Winter WE , Maxwell GL , Tian CQ , Carlson JW , Ozols RF , Rose PG , Markman M , Armstrong DK , Muggia F , McGuire WP
Prognostic factors for stage III epithelial ovarian cancer: A Gynecologic Oncology Group Study
Journal of Clinical Oncology. 2007 Aug;25(24) :3621-3627
AbstractPurpose Conflicting results on prognostic factors for advanced epithelial ovarian cancer ( EOC) have been reported because of small sample size and heterogeneity of study population. The purpose of this study was to identify factors predictive of poor prognosis in a similarly treated population of women with advanced EOC. Patients and Methods A retrospective review of demographic, pathologic, treatment, and outcome data from 1,895 patients with International Federation of Gynecology and Obstetrics stage III EOC who had undergone primary surgery followed by six cycles of intravenous platinum/paclitaxel was conducted. A proportional hazards model was used to assess the association of prognostic factors with progression-free survival ( PFS) and overall survival ( OS). Results Increasing age was associated with increased risks for disease progression ( HR = 1.06; 95% CI, 1.02 to 1.11 for an increase every 10 years) and death ( HR = 1.12; 95% CI, 1.06 to 1.18). Mucinous or clear-cell histology was associated with a worse PFS and OS compared with serous carcinomas. Patients with performance status ( PS) 1 or 2 were at an increased risk for recurrence compared with PS 0 ( HR = 1.12; 95% CI, 1.01 to 1.24). Compared with patients with microscopic residual disease, patients with 0.1 to 1.0 cm and > 1.0 cm residual disease had an increased risk of recurrence ( HR = 1.96; 95% CI, 1.70 to 2.26; and HR = 2.36; 95% CI, 2.04 to 2.73, respectively) and death ( HR = 2.11; 95% CI, 1.78 to 2.49; P < .001; and HR = 2.47; 95% CI, 2.09 to 2.92, respectively). Conclusion Age, PS, tumor histology, and residual tumor volume were independent predictors of prognosis in patients with stage III EOC. These data can be used to identify patients with poor prognosis and to design future tailored randomized clinical trials.
NotesISI Document Delivery No.: 209VK Times Cited: 0 Cited Reference Count: 39 Cited References: AKAHIRA JI, 2001, GYNECOL ONCOL, V81, P398 ARMSTRONG DK, 2006, NEW ENGL J MED, V354, P34 BARNHOLTZSLOAN JS, 2002, CANCER, V94, P1886 BRISTOW RE, 1999, GYNECOL ONCOL, V72, P278 CHAN JK, 2003, OBSTET GYNECOL, V102, P156 CHI DS, 2001, GYNECOL ONCOL, V82, P532 CLARK TG, 2001, BRIT J CANCER, V85, P944 CORNELISON TL, 1993, CANCER, V71, P650 DAYA D, 1992, AM J CLIN PATHOL, V97, P751 DUSKA LR, 1999, CANCER, V85, P2623 GERSELL DJ, 1992, AM J CLIN PATHOL, V97, P745 GRONLUND B, 2002, CANCER, V94, P1961 HARLAN LC, 2003, J CLIN ONCOL, V21, P3488 HESS V, 2004, J CLIN ONCOL, V22, P1040 HOSKINS WJ, 1989, GYNECOL ONCOL, V34, P365 HOSKINS WJ, 1992, GYNECOL ONCOL, V47, P159 HOSKINS WJ, 1994, AM J OBSTET GYNECOL, V170, P974 JEMAL A, 2005, CA-CANCER J CLIN, V55, P10 LUND B, 1990, CANCER RES, V50, P4626 MARKMAN M, 2001, J CLIN ONCOL, V19, P1001 MARSONI S, 1990, BRIT J CANCER, V62, P444 MASSI D, 1996, CANCER, V77, P1131 MCGUIRE WP, 1996, NEW ENGL J MED, V334, P1 MUGGIA FM, 2000, J CLIN ONCOL, V18, P106 NG LW, 1990, GYNECOL ONCOL, V38, P358 NISHIZUKA S, 2003, CANCER RES, V63, P5243 OMURA GA, 1991, J CLIN ONCOL, V9, P1138 OZOLS RF, 2003, J CLIN ONCOL, V21, P3194 PARHAM G, 1997, CANCER, V80, P816 PARMAR MKB, 2002, LANCET, V360, P505 PLAXE SC, 1993, OBSTET GYNECOL, V81, P651 RIES LAG, 1993, CANCER, V71, P524 RODRIGUEZ M, 1994, CANCER, V73, P1245 ROSE PG, 2004, NEW ENGL J MED, V351, P2489 THIGPEN T, 1993, CANCER, V71, P606 TSAI JY, 2001, CANCER, V91, P2065 VANDERBURG MEL, 1995, NEW ENGL J MED, V332, P629 VERGOTE I, 2001, LANCET, V357, P176 ZOM KK, 2003, GYNECOL ONCOL, V88, A90