FCCC LOGO Faculty Publications
Ramcharan J , Skalka AM
Strategies for identification of HIV-1 integrase inhibitors
Future Virology. 2006 Nov;1(6) :717-731
PMID: ISI:000249426400008   
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HIV-1 integrase, which catalyzes the joining of viral DNA to the host cell DNA, has attracted considerable attention as a target for the design and screening of novel anti-HIV drugs as it is essential for virus replication and the establishment of persistent infection. Progress in the identification of different classes of compounds that block integrase activity has been summarized recently in several excellent reviews. Here, we present a brief overview of integrase inhibition, highlighting some of the unusual properties of this protein and important considerations in searching for potential new inhibitors and their evaluation.
ISI Document Delivery No.: 209ZL Times Cited: 1 Cited Reference Count: 116 Cited References: AGAPKINA J, 2006, J BIOL CHEM, V281, P11530 ASANTEAPPIAH E, 1997, J BIOL CHEM, V272, P16196 ASANTEAPPIAH E, 1998, J BIOL CHEM, V273, P35078 ASANTEAPPIAH E, 1999, ADV VIRUS RES, V52, P351 ASON B, 2005, ANTIMICROB AGENTS CH, V49, P2035 BAO KK, 2002, J BIOL CHEM, V277, P12099 BAO KK, 2003, J BIOL CHEM, V278, P1323 BARRECA ML, 2006, J MED CHEM, V49, P3994 BONNENFANT S, 2004, J VIROL, V78, P5728 BUSHMAN FD, 1993, P NATL ACAD SCI USA, V90, P3428 CHEN AP, 2006, J BIOL CHEM, V281, P4173 CHEN JCH, 2000, P NATL ACAD SCI USA, V97, P8233 CHEN ZG, 2000, J MOL BIOL, V296, P521 CHEREPANOV P, 1997, MOL PHARMACOL, V52, P771 CHEREPANOV P, 2005, P NATL ACAD SCI USA, V102, P17308 COFFIN JM, 1997, COLD SPRING HARBOR L, P161 COLEMAN J, 1999, J BIOL CHEM, V274, P32842 CRAIGIE R, 1991, NUCLEIC ACIDS RES, V19, P2729 DANIEL R, 1999, SCIENCE, V284, P644 DANIEL R, 2001, MOL CELL BIOL, V21, P1164 DANIEL R, 2003, P NATL ACAD SCI USA, V100, P4778 DANIEL R, 2004, AIDS RES HUM RETROV, V20, P135 DANIEL R, 2004, J VIROL, V78, P8573 DANIEL R, 2005, J VIROL, V79, P2058 DAYAM R, 2006, AIDS PATIENT CARE ST, V26, P271 DEBYSER Z, 2001, METHOD MOL BIOL, V160, P139 DECLERCQ E, 2006, FUTURE VIROLOGY, V1, P19 DEPREZ E, 2000, BIOCHEMISTRY-US, V39, P9275 DEPREZ E, 2004, MOL PHARMACOL, V65, P85 ELLISON V, 1994, P NATL ACAD SCI USA, V91, P7316 ELLISON V, 1995, J BIOL CHEM, V270, P3320 ENGELMAN A, 1993, EMBO J, V12, P3269 ESPOSITO D, 1998, EMBO J, V17, P5832 ESTE JA, 1998, MOL PHARMACOL, V53, P340 FARNET CM, 1996, P NATL ACAD SCI USA, V93, P9742 FAURE A, 2005, NUCLEIC ACIDS RES, V33, P977 FESEN MR, 1994, BIOCHEM PHARMACOL, V48, P595 FLINT SJ, 2000, PRINCIPLES VIROLOGY, P216 GAO K, 2001, EMBO J, V20, P3565 GOLDGUR Y, 1998, P NATL ACAD SCI USA, V95, P9150 GOLDGUR Y, 1999, P NATL ACAD SCI USA, V96, P13040 GROBLER JA, 2002, P NATL ACAD SCI USA, V99, P6661 GUIOT E, 2006, J BIOL CHEM, V281, P22707 HAZUDA DJ, 1994, NUCLEIC ACIDS RES, V22, P1121 HAZUDA DJ, 1997, J VIROL, V71, P7005 HAZUDA DJ, 2000, SCIENCE, V287, P646 HAZUDA DJ, 2004, ADV ANTIVIRAL DRUG D HAZUDA DJ, 2004, SCIENCE, V305, P528 HINDMARSH P, 1999, J VIROL, V73, P2994 HWANG Y, 2000, NUCLEIC ACIDS RES, V28, P4884 JACQUE JM, 2006, NATURE, V441, P641 JENKINS TM, 1995, P NATL ACAD SCI USA, V92, P6057 JENKINS TM, 1996, J BIOL CHEM, V271, P7712 JOHN S, 2005, J BIOMOL SCREEN, V10, P606 JOHNSON AA, 2004, CURR TOP MED CHEM, V4, P1059 JONES KS, 1992, J BIOL CHEM, V267, P16037 KARKI RG, 2004, J COMPUT AID MOL DES, V18, P739 KATZMAN M, 1989, J VIROL, V63, P5319 KATZMAN M, 1996, J VIROL, V70, P9069 LATAILLADE M, 2006, AIDS PATIENT CARE ST, V20, P489 LAU A, 2005, NAT CELL BIOL, V7, P493 LEE MS, 1994, P NATL ACAD SCI USA, V91, P9823 LEE SP, 1997, BIOCHEMISTRY-US, V36, P173 LEH H, 2000, BIOCHEMISTRY-US, V39, P9285 LEVYMINTZ P, 1996, J VIROL, V70, P8821 LI M, 2005, J BIOL CHEM, V280, P29334 LI M, 2006, EMBO J, V25, P1295 LI XN, 2006, BIOORGAN MED CHEM, V14, P2942 LI XN, 2006, BIOORGAN MED CHEM, V14, P5742 LIN CW, 2003, J VIROL, V77, P5030 LINS RD, 2000, BIOPOLYMERS, V53, P308 LINS RD, 2000, PHARMACOL THERAPEUT, V85, P123 LLANO M, 2006, SCI EXPRESS LUBKOWSKI J, 1998, P NATL ACAD SCI USA, V95, P4831 LUTZKE RAP, 1998, J VIROL, V72, P4841 MARCHAND C, 2003, MOL PHARMACOL, V64, P600 MAZUMDER A, 1996, J BIOL CHEM, V271, P27330 MEADOWS DC, 2006, CHEMEDCHEM, V1, P16 MEANWELL NA, 2004, CURR DRUG TARGETS IN, V5, P307 MOLTENI V, 2001, ACTA CRYSTALLOGR D 4, V57, P536 MORALESRAMIREZ JO, 2005, P 10 EUR AIDS C DUBL MOUSNIER A, 2004, MOL PHARMACOL, V66, P783 NAIR V, 2002, REV MED VIROL, V12, P179 NAIR V, 2006, J MED CHEM, V49, P445 NAREZKINA A, 2004, J VIROL, V78, P11656 NEAMATI N, 1997, MOL PHARMACOL, V52, P1041 NEAMATI N, 1998, J MED CHEM, V41, P3202 NUNNARI G, 2005, VIROLOGY, V335, P177 PANNECOUQUE C, 2002, CURR BIOL, V12, P1169 PETTERSSON S, 2006, MINI-REV MED CHEM, V6, P91 PLUYMERS W, 2000, MOL PHARMACOL, V58, P641 PODTELEZHNIKOV AA, 2003, BIOPOLYMERS, V68, P110 POMMIER Y, 2005, NAT REV DRUG DISCOV, V4, P236 SATO M, 2006, J MED CHEM, V49, P1506 SCHRODER ARW, 2002, CELL, V110, P521 SHEHUXHILAGA M, 2005, CURR MED CHEM, V12, P1705 SINHA S, 2005, J VIROL, V79, P8208 SKALKA AM, 2005, CELL DEATH DIFFER S1, V12, P971 TURELLI P, 2001, MOL CELL, V7, P1245 VANGENT DC, 1993, EMBO J, V12, P3261 VANMAELE B, 2005, AIDS REV, V7, P26 VANMAELE B, 2006, TRENDS BIOCHEM SCI, V31, P98 VINK C, 1994, NUCLEIC ACIDS RES, V22, P4103 WANG JY, 2001, EMBO J, V20, P7333 WANG Y, 2005, J BIOMOL SCREEN, V10, P456 WIELENS J, 2005, J COMPUT AID MOL DES, V19, P301 WITVROUW M, 2004, CURR DRUG METAB, V5, P291 WOLFE AL, 1996, J VIROL, V70, P1424 WU XL, 2003, SCIENCE, V300, P1749 YANG ZN, 2000, J MOL BIOL, V296, P535 YI JZ, 1999, BIOCHEMISTRY-US, V38, P8458 ZHANG XC, 2003, BIOORG MED CHEM LETT, V13, P1215 ZHAO H, 1997, J MED CHEM, V40, P937 ZHENG RL, 1996, P NATL ACAD SCI USA, V93, P13659 ZHUANG LC, 2003, J MED CHEM, V46, P453 ZOUHIRI F, 2000, J MED CHEM, V43, P1533