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Kruh GD , Belinsky MG , Gallo JM , Lee K
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice
Cancer Metastasis Rev. 2007 Feb 2;26(1) :5-14
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The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.
Ca06927/ca/nci Ca114574/ca/nci Ca72937/ca/nci Ca73728/ca/nci Ca85577/ca/nci Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Netherlands