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Jin L , Wang L , Li J , Luo W , Feigenberg SJ , Ma CM
Investigation of optimal beam margins for stereotactic radiotherapy of lung-cancer using Monte Carlo dose calculations
Physics in Medicine and Biology. 2007 Jun;52(12) :3549-3561
PMID: ISI:000247047800014   
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This work investigated the selection of beam margins in lung-cancer stereotactic body radiotherapy (SBRT) with 6 MV photon beams. Monte Carlo dose calculations were used to systematically and quantitatively study the dosimetric effects of beam margins for different lung densities (0.1, 0.15, 0.25, 0.35 and 0.5 g cm(-3)), planning target volumes (PTVs) (14.4, 22.1 and 55.3 cm(3)) and numbers of beam angles ( three, six and seven) in lung-cancer SBRT in order to search for optimal beam margins for various clinical situations. First, a large number of treatment plans were generated in a commercial treatment planning system, and then recalculated using Monte Carlo simulations. All the plans were normalized to ensure that 95% of the PTV at least receives the prescription dose and compared quantitatively. Based on these plans, the relationships between the beam margin and quantities such as the lung toxicity (quantified by V-20, the percentage volume of the two lungs receiving at least 20 Gy) and the maximum target ( PTV) dose were established for different PTVs and lung densities. The impact of the number of beam angles on the relationship between V20 and the beam margin was assessed. Quantitative information about optimal beam margins for lung-cancer SBRT was obtained for clinical applications.