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Dorgan JF , McMahon RP , Friedman LA , Van Horn L , Snetselaar LG , Kwiterovich PO Jr , Lauer RM , Lasser NL , Stevens VJ , Robson A , Cooper SF , Chandler DW , Franklin FA , Barton BA , Patterson BH , Taylor PR , Schatzkin A
Diet and sex hormones in boys: findings from the dietary intervention study in children
J Clin Endocrinol Metab. 2006 Oct;91(10) :3992-6
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CONTEXT: Diet reportedly alters serum sex hormone concentrations in adults, but little is known about the influence of diet during puberty on these hormones. OBJECTIVE: We aimed to determine whether an intervention to lower fat intake during adolescence alters serum sex hormone concentrations and progression through puberty. DESIGN: In 1990-1997, we conducted an ancillary study to the Dietary Intervention Study in Children, a multicenter, randomized, controlled clinical trial to test the safety and efficacy of a cholesterol-lowering dietary intervention in children. PARTICIPANTS: Healthy, prepubertal, 8 to 10 yr olds with elevated low-density lipoprotein cholesterol were randomized to usual care or a behavioral intervention. Of 362 randomized Dietary Intervention Study in Children boys, 354 participated in the ancillary study. Eighty-four percent of boys attended last visits when their median time on trial was 7.1 yr. INTERVENTION: The behavioral intervention continued throughout the duration of the trial and promoted a diet with 28% energy from total fat, less than 8% from saturated fat, 9% or less from polyunsaturated fat, and less than 75 mg cholesterol per 1000 kcal. OUTCOME MEASURES: The main outcome measure for boys formulated before study initiation was non-SHBG bound testosterone concentration. Secondary outcomes included serum total testosterone, dihydrotestosterone, androstenedione, estradiol, estrone, SHBG, and Tanner stage. RESULTS: There were no significant treatment group differences in boys' serum hormone levels, SHBG, or Tanner stages at any individual visit or over the course of the trial when evaluated by longitudinal models. CONCLUSION: Modest reductions in total fat, saturated fat, and possibly energy intake do not alter progression through puberty or serum sex hormone concentrations in adolescent boys.
U01 hl 37947/hl/nhlbi U01 hl 37948/hl/nhlbi U01 hl 37954/hl/nhlbi U01 hl 37962/hl/nhlbi U01 hl 37966/hl/nhlbi U01 hl 37975/hl/nhlbi U01 hl 38110/hl/nhlbi Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural United States