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Xu RH , Fang M , Klein-Szanto A , Sigal LJ
Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26) :10992-7
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It is uncertain how immunity protects against systemic viral diseases. Here, we demonstrate that in the absence of persistent virus, not only antibodies but also recall responses by long-lived memory CD8(+) T cells prevent mousepox, a disease caused by ectromelia virus, a close relative of the virus of human smallpox. Moreover, we show that to protect, recall CD8(+) T cells directly kill targets in the lymph node draining the primary site of infection thus curbing systemic viral spread. Therefore, our work provides the basis for a model where lymph nodes are not just organs where lymphocytes become activated and proliferate but also the sites where a major fight against virus spread takes place.
Journal Article United States