FCCC LOGO Faculty Publications
Lerman C , Shields PG , Audrain J , Main D , Cobb B , Boyd NR , Caporaso N
The role of the serotonin transporter gene in cigarette smoking
Cancer Epidemiology Biomarkers & Prevention. 1998 Mar;7(3) :253-255
PMID: ISI:000072384000014   
Back to previous list
Data from twin studies have suggested that cigarette smoking has a significant heritable component, The serotonin transporter gene (5-HTT) is a plausible candidate gene for smoking predisposition because of its association with psychological traits relevant to smoking behavior, The present investigation evaluated the associations of smoking practices and smoking cessation with a common polymorphism in the upstream regulatory region of 5-HTT that is manifested as either an inserted (long) variant or a deleted (short) variant, The short variant of the polymorphism is associated with reduced transcription of the gene promoter and diminished uptake, A case-control study design (268 smokers and 230 controls) was used to evaluate the associations of 5-HTT genotype with smoking status, Case series analysis of smokers was used to evaluate the role of 5-HTT in age at smoking initiation, previous quitting history, current smoking rate, and 12-month quit rate following a minimal-contact smoking cessation program, There were no significant differences in the distribution of 5-HTT genotypes in smokers as compared with nonsmokers in either Caucasians or African Americans, nor was the 5-HTT genotype associated with the smoking outcome variables, However, the results did reveal significant racial differences in the distribution of 5-HTT genotypes: Caucasians were significantly more likely to carry the short variant of the 5-HTT gene than mere African Americans (P = 0.005), These findings suggest that the 5-HTT gene may not play a significant role in cigarette smoking practices.
Times Cited: 9 English Article ZA627 CANCER EPIDEM BIOMARKER PREV