FCCC LOGO Faculty Publications
Holroyd KJ , Martinati LC , Trabetti E , Scherpbier T , Eleff SM , Boner AL , Pignatti PF , Kiser MB , Dragwa CR , Hubbard F , Sullivan CD , Grasso L , Messler CJ , Huang MX , Hu Y , Nicolaides NC , Buetow KH , Levitt RC
Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region
Genomics. 1998 Sep 1;52(2) :233-235
PMID: ISI:000076421700018   
Back to previous list
We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate. (C) 1998 Academic Press.
Times Cited: 25 English Article 128TD GENOMICS