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Tuluc M , Zhang XM , Inniss S
Giant cell tumor of the nasal cavity: case report
European Archives of Oto-Rhino-Laryngology. 2007 Feb;264(2) :205-208
PMID: ISI:000243000300016   
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Soft tissue giant cell tumor of low malignant potential is a rare tumor located in superficial and deep soft tissue. Tumors with osteoclast-like giant cells have been reported in various sites as breast, salivary glands, lung, kidney and pancreas. These tumors are composed of evenly spaced multinucleated giant cells in a background of mononuclear component composed of round, oval or spindled cells. No atypia or significant mitotic activity is encountered. Immunohistochemical stains for TRAP, smooth muscle actin, desmin and cytokeratins are of great value for diagnosis. Nasal cavity represents a very unusual location for this type of tumors; soft tissue tumors must be included in the differential diagnosis of nasal obstruction. Due to the possibility of local recurrence, clinical follow-up is recommended.
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