FCCC LOGO Faculty Publications
Cohen RB , Dittrich KA
Anti-TNF therapy and malignancy - a critical review
Can J Gastroenterol. 2001 Jun;15(6) :376-84
Back to previous list
The roles of tumour necrosis factor (TNF) and anti-TNF therapy in malignancy are reviewed, including an overview of baseline risk factors for malignancy in inflammatory diseases and the incidences of malignancies observed in clinical trials of an anti-TNF-a therapy, infliximab. The preclinical data and early clinical experience presented for infliximab do not provide evidence for a causal relationship between TNF-a antagonism and the development of lymphoid or nonlymphoid cancers.
0835-7900 Journal Article Review Review, Tutorial