FCCC LOGO Faculty Publications
Hardy RR
B-1 B cell development
J Immunol. 2006 Sep 1;177(5) :2749-54
PMID: 16920907   
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CD5(+) B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5(+) B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5(+) B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.