FCCC LOGO Faculty Publications
Adams GP
Improving the tumor specificity and retention of antibody-based molecules
In Vivo. 1998 Jan-Feb;12(1) :11-21
PMID: ISI:000073819000002   
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Abstract
A number of novel strategies have been employed to enhance the degree and specificity of tumor-targeting by antibody-based molecules. These fall into three overlapping categories. The augmentation of the interaction between the antibody and target antigen (e.g., through increased affinity or valence), the enhancement of targeting specificity (e.g., by altering the clearance of unbound antibody ol radiolabel), and the selection of radioisotopes and labeling methods which are more stable in vivo or better suited to the target application.
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Times Cited: 16 English Article ZQ076 IN VIVO