FCCC LOGO Faculty Publications
Hardy RR
Development of murine B cell subpopulations
Seminars in Immunology. 1990 ;2(3) :197-206
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The generation of diverse B cell subpopulations in the mouse is the subject of considerable current interest. In this review, I first describe a general framework for antigen-independent B cell differentiation in the adult bone marrow including results from in vitro culture systems. In following sections, effects on B cell development in several immunodefitient strains and transgenic lines are presented. Next, the CD5+ B cell subpopulation is covered in some depth, including data on development, physiology and repertoire selection. Finally, another selected population, memory B cells, together with their likely origins in the germinal center are discussed. © 1990 by W.B. Saunders Company.
10445323 (ISSN) Cited By: 5; Export Date: 30 May 2006; Source: Scopus CODEN: SEIME Language of Original Document: English Correspondence Address: Hardy, R.R.; I.C.R.; Fox Chase Cancer Center Philadelphia, PA 19111, United States Chemicals/CAS: Antigens, CD; Antigens, CD5