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Smits KM , Benhamou S , Garte S , Weijenberg MP , Alamanos Y , Ambrosone C , Autrup H , Autrup JL , Baranova H , Bathum L , Boffetta P , Bouchardy C , Brockmoller J , Butkiewicz D , Cascorbi I , Clapper ML , Coutelle C , Daly AK , Muzi G , Dolzan V , Duzhak TG , Farker K , Golka K , Haugen A , Hein DW , Hildesheim A , Hirvonen A , Hsieh LL , Ingelman-Sundberg M , Kalina I , Kang D , Katoh T , Kihara M , Ono-Kihara M , Kim H , Kiyohara C , Kremers P , Lazarus P , Le Marchand L , Lechner MC , London S , Manni JJ , Maugard CM , Morgan GJ , Morita S , Nazar-Stewart V , Kristensen VN , Oda Y , Parl FF , Peters WHM , Rannug A , Rebbeck T , Pinto LFR , Risch A , Romkes M , Salagovic J , Schoket B , Seidegard J , Shields PG , Sim E , Sinnett D , Strange RC , Stucker I , Sugimura H , To-Figueras J , Vineis P , Yu MC , Zheng W , Pedotti P , Taioli E
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
International Journal of Cancer. 2004 Jun;110(2) :266-270
AbstractPolymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking ! dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected. (C) 2004 Wiley-Liss, Inc.
NotesEnglish Article Taioli, E; Osped Policlin, Unit Mol & Genet Epidemiol, IRCCS, Padiglione Marangoni,Via F Sforza 35, I-20122 Milan, Italy. Research Addresses: Osped Maggiore, Ist Ric & Cuza Carrattere Sci, Mol & Genet Epidemiol Unit, Milan, Italy. Vanderbilt Univ, Med Ctr, Nashville, TN USA. Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei 10764, Taiwan. Univ Turin, Coll Publ Hlth, Inst Epidemiol, Turin, Italy. Univ Turin, Turin, Italy. Hosp Clin Barcelona, Barcelona, Spain. Hamamatsu Univ, Sch Med, Shizuoka, Japan. Keele Univ, Keele, Staffs, England. Hop St Justine, Montreal, PQ H3T 1C5, Canada. Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England. Georgetown Univ, Med Ctr, Washington, DC 20007 USA. Lund Univ, Lund, Sweden. Natl Inst Environm Hlth, Budapest, Hungary. Univ Pittsburgh, Pittsburgh, PA 15260 USA. Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany. Dept Bioquim, Rio De Janeiro, Brazil. Univ Penn, Sch Med, Philadelphia, PA 19104 USA. Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden. Univ Hosp Nijmegen, Nijmegen, Netherlands. Vanderbilt Univ, Nashville, TN USA. Kanazawa Univ, Kanazawa, Ishikawa 920, Japan. Norwegian Radium Hosp, Inst Canc Res, Oslo, Norway. Oregon Hlth Sci Univ, Portland, OR 97201 USA. Yao Municipal Hosp, Osaka, Japan. Univ Leeds, Gen Infirm, Leeds LS1 3EX, W Yorkshire, England. Ctr Rene Gauducheau, F-44035 Nantes, France. Univ Hosp Maastricht, Maastricht, Netherlands. Natl Inst Environm Hlth Sci Res, Res Triangle Pk, NC USA. Univ Lisbon, P-1699 Lisbon, Portugal. Univ Hawaii, Honolulu, HI 96822 USA. H Lee Moffit Canc Ctr & Res Inst, Tampa, FL USA. Inst Pathol, Liege, Belgium. Kyushu Univ, Fukuoka 812, Japan. Chungbuk Natl Univ, Chungbuk, South Korea. Kyoto Univ, Sch Publ Hlth, Kyoto, Japan. Miyazaki Med Coll, Miyazaki 88916, Japan. Seoul Natl Univ, Coll Med, Seoul, South Korea. Safarik Univ, Kosice, Slovakia. Karolinska Inst, Stockholm, Sweden. Chang Gung Univ, Tao Yuan, Taiwan. Finnish Inst Occupat Hlth, Helsinki, Finland. NCI, Rockville, MD USA. Univ Louisville, Louisville, KY 40292 USA. Natl Inst Occupat Hlth, Oslo, Norway. Univ Dortmund, Inst Occupat Physiol, Dortmund, Germany. Univ Jena, Inst Clin Pharmcol, D-6900 Jena, Germany. Univ Ljubljana, Ljubljana, Slovenia. Inst Med Lavoro, Perugia, Italy. Univ Newcastle Upon Tyne, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. Univ Bordeaux 2, F-33076 Bordeaux, France. *Fox* *Chase* Canc Ctr, Philadelphia, PA 19111 USA. Univ Greifswald, Greifswald, Germany. Ctr Oncol, Gliwice, Poland. Univ Gottingen, Dept Clin Pharmacol, D-3400 Gottingen, Germany. Int Agcy Res Canc, F-69372 Lyon, France. Unvi Auvergne, Clermont Ferrand, France. Univ Aarhus, Aarhus, Denmark. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. Univ Ioannina, GR-45110 Ioannina, Greece. Genet Res Inst, Milan, Italy. Geneva Canc Registry, Geneva, Switzerland. INSERM, Villejuif, France. Univ Maastricht, Maastricht, Netherlands. Cited References: BEGG CB, 1994, CANCER EPIDEM BIOMAR, V3, P173 BENHAMOU S, 2002, CARCINOGENESIS, V23, P1343 CAPORASO NE, 2001, CANCER EPIDEM BIOMAR, V10, P261 CHOLERTON S, 1994, LANCET, V343, P62 CHOLERTON S, 1996, PHARMACOGENETICS, V6, P261 GARTE S, 2001, CANCER EPIDEM BIOMAR, V10, P1239 LERMAN C, 2003, AM J MED GENET, V11, P48 LONDON SJ, 1999, LANCET, V353, P898 MCBRIDE CM, 2002, CANCER EPIDEM BIOMAR, V11, P521 RAUNIO H, 1995, GENE, V159, P113 SAARIKOSKI ST, 2000, PHARMACOGENETICS, V10, P5 SHIELDS PG, 1998, CANCER EPIDEM BIOMAR, V7, P453 TAIOLI E, 1999, CANCER EPIDEM BIOMAR, V8, P727 TYNDALE RF, 2001, DRUG METAB DISPOS, V29, P548 VINEIS P, 1999, METABOLIC POLYMORPHI WALTON R, 2001, TRENDS MOL MED, V7, P70 Number of cited references: 16 Number of times cited: 0 Publisher: WILEY-LISS; DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA. 0020-7136