FCCC LOGO Faculty Publications
Manchester M , Rall GF
Model Systems: transgenic mouse models for measles pathogenesis
Trends Microbiol. 2001 Jan;9(1) :19-23
Back to previous list
Studies of the diseases caused by measles virus (MV) in humans have been restricted owing to the lack of suitable animal models. The discovery of cellular receptors for MV entry has facilitated the development of transgenic mice that are susceptible to MV infection, and that mimic certain aspects of the central nervous system diseases and immunosuppression that can occur in infected humans. Moreover, such mouse models have allowed a clearer understanding of the contributions of the innate and adaptive immune response following infection, and will no doubt be important tools in the future for the development of new antiviral and vaccine reagents.
21109315 0966-842x Journal Article Review Review, Tutorial