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Lu Q , Guo Q , Xin M , Lim C , Gamero AM , Gerhard GS , Yang L
LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling
Noncoding RNA. 2021 Aug 28;7(3)
PMID: 34564314    PMCID: PMC8482154    URL: https://www.ncbi.nlm.nih.gov/pubmed/34564314
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Abstract
Long non-coding RNA (lncRNA) TP53 target 1 (TP53TG1) was discovered as a TP53 target gene. TP53TG1 has been reported as having dual roles by exerting tumor-suppressive and oncogenic activities that vary depending on the cancer type. Yet, the role of TP53TG1 in hepatocellular carcinoma (HCC) is not fully understood. In this study, we performed both gain- and loss-of-function studies to determine the biological role of TP53TG1 in HCC. We found that the knockdown of TP53 in HCC cells caused the upregulation of TP53TG1. Furthermore, we found that the knockdown of TP53TG1 not only suppressed HCC cell proliferation and migration, but also reduced intrinsic ERK signaling. In contrast, the overexpression of TP53TG1 increased ERK activation and enhanced HCC proliferation. In conclusion, our study reveals an oncogenic role of TP53TG1 in HCC, which provides a novel insight into the cell-type-specific function of TP53TG1 in HCC.
Notes
2311-553x Lu, Qingchun Guo, Qian Xin, Mingyang Lim, Casey Gamero, Ana M Orcid: 0000-0001-7843-1415 Gerhard, Glenn S Orcid: 0000-0001-6276-0337 Yang, Ling Orcid: 0000-0002-7586-3922 K22 HL139921/HL/NHLBI NIH HHS/United States 5U54CA221705/NH/NIH HHS/United States K22HL139921/NH/NIH HHS/United States Journal Article Noncoding RNA. 2021 Aug 28;7(3):52. doi: 10.3390/ncrna7030052.