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Cuffee YL , Wang M , Geyer NR , Saxena S , Akuley S , Jones L , Wilson RT
Vitamin D and family history of hypertension in relation to hypertension status among college students
J Hum Hypertens. 2021 Jul 20
PMID: 34285353   
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Hypertension and vitamin D concentrations have heritable components, although these factors remain uninvestigated in young adults. The objective of this study was to investigate hypertension risk among young adults with respect to family history of hypertension, adjusting for vitamin D status. Resting blood pressure (BP) was measured in 398 individuals aged 18-35 and classified according to the 2017 American Heart Association criteria. Plasma vitamin D metabolite (25(OH)D(3); 24,25(OH)(2)D(3); 1,25(OH)(2)D(3)) concentrations were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Stepwise logistic regression was used to select covariates. Participants' mean age was 21, 30.3% had hypertension, and nearly all unaware of their hypertensive status (90.7%). Compared with no parental history, the adjusted odds ratio (AOR) for hypertension was elevated among participants with two parents having hypertension (AOR = 4.5, 95% CI: 1.70-11.76), adjusting for sex, body mass index, physical activity, and plasma 25(OH)D(3). Results for systolic hypertension (SH) were similar but more extreme (two parents AOR = 7.1, 95% CI: 2.82, 17.66), although dihydroxy metabolites (1,25(OH)(2)D(3) and 24,25(OH)(2)D(3)) were significant. There was a strong, independent association with dual parental history and hypertension status, regardless of vitamin D status. Hypertension was prevalent in nearly one-third of the sample and underscores the need for targeted prevention for young adults.
1476-5527 Cuffee, Yendelela L Orcid: 0000-0001-7150-0086 Wang, Ming Geyer, Nathaniel R Orcid: 0000-0003-0965-3123 Saxena, Sangeeta Akuley, Suzanne Jones, Lenette Wilson, Robin Taylor Orcid: 0000-0002-5739-558x K22 CA120092/CA/NCI NIH HHS/United States UL1 TR000127/TR/NCATS NIH HHS/United States Journal Article England J Hum Hypertens. 2021 Jul 20. doi: 10.1038/s41371-021-00577-6.