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Murine BST2/tetherin promotes measles virus infection of neurons
Virology. 2021 Nov;563 :38-43
PMID: 34416448    PMCID: PMC8491112    URL: https://www.ncbi.nlm.nih.gov/pubmed/34416448
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BST2/tetherin is a transmembrane protein with antiviral activity; it is synthesized following exposure to interferons, and restricts the release of budding virus particles by tethering them to the host cell membrane. We previously showed that BST2 is induced in primary neurons following measles virus (MV) infection or type I interferon; however, BST2 was dispensable for protection against challenge with neuron-restricted MV. Here, we define the contribution of BST-2 in neuronal MV infection. Surprisingly, and in contrast to its antiviral role in non-neuronal cells, murine BST2 promotes MV infection in brains of permissive mice and in primary neuron cultures. Moreover, BST2 expression was predominantly observed in the non-synaptic fraction of purified neurons. These studies highlight a cell-type dependent role of a well-characterized antiviral protein in enhancing neuronal infection.
Miller, Katelyn D Matullo, Christine Williams, Riley Jones, Carli B Rall, Glenn F eng F31 NS092307/NS/NINDS NIH HHS/ P30 CA006927/CA/NCI NIH HHS/ T32 NS007180/NS/NINDS NIH HHS/ Virology. 2021 Nov;563:38-43. doi: 10.1016/j.virol.2021.08.005. Epub 2021 Aug 15.